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Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors

✍ Scribed by Shepherd, Timothy A.; Aikins, James A.; Bleakman, David; Cantrell, Buddy E.; Rearick, John P.; Simon, Richard L.; Smith, Edward C. R.; Stephenson, Gregory A.; Zimmerman, Dennis M.; Mandelzys, Allan; Jarvie, Keith R.; Ho, Ken; Deverill, Michelle; Kamboj, Rajender K.


Book ID
120932311
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
112 KB
Volume
45
Category
Article
ISSN
0022-2623

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We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com