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Berbanes: a new class of selective .alpha.2-adrenoceptor antagonists

โœ Scribed by Vizi, E. Sylvester; Toth, Istvan; Somogyi, George T.; Szabo, Lajos; Harsing, Laszlo G.; Szantay, Csaba

Book ID
126967326
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
658 KB
Volume
30
Category
Article
ISSN
0022-2623

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Synthesis of a selective alpha-2A adreno
Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors
โœ Lee J. Beeley; John M. Berge; Helen Chapman; Paul Hieble; John Kelly; Diane P. N ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 493 KB

The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.