Synthesis of Benzodioxinopyrroles as sel
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J. Kitchin; A.D. Borthwick; A.C. Brodie; P.C. Cherry; A.J. Crame; A.J. Pipe; P.A
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Article
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1995
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Elsevier Science
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English
⚖ 727 KB
A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective alpha 2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analo