๐”– Bobbio Scriptorium
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CGS 7525A, A new, centrally active alpha2 adrenoceptor antagonist

โœ Scribed by Jeffrey M. Liebman; Richard A. Lovell; Albert Braunwalder; George Stone; Patrick Bernard; Beverly Barbaz; James Welch; Heh Soon Kim; Jan W.F. Wasley; Ronald D. Robson


Book ID
118941620
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
580 KB
Volume
32
Category
Article
ISSN
0024-3205

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Synthesis of a selective alpha-2A adreno
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The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.