✦ LIBER ✦

Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors

✍ Scribed by Lee J. Beeley; John M. Berge; Helen Chapman; Paul Hieble; John Kelly; Diane P. Naselsky; Caroline M. Rockell; Paul W. Young

Book ID: 103992181
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 493 KB
Volume: 3
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(95)00157-3

No coin nor oath required. For personal study only.

✦ Synopsis

The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.

📜 SIMILAR VOLUMES

Cardiovascular effects of a selective al

Cardiovascular effects of a selective alpha1-adrenoceptor antagonist and Ca2+-entry blocker: GYKY-12 743

✍ Jaszlits L.; Csókás Gy.; Rabloczky Gy.; Cseh Gy.; Berzétei I.; Kasztreiner E. 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 80 KB

Synthesis and structure-activity relatio

Synthesis and structure-activity relationships of 2-sulfonamido-1,3,4,6,7,11b.alpha.-hexahydro-2H-benzo[a]quinolizines as .alpha.2-adrenoceptor antagonists

✍ Ward, Terence J.; White, John F.; Lattimer, Norman; Rhodes, Keith F.; Sharma, Sh 📂 Article 📅 1988 🏛 American Chemical Society 🌐 English ⚖ 842 KB

The use of two novel alpha 2 adrenocepto

The use of two novel alpha 2 adrenoceptor antagonists, idazoxan and its analogue RX821002A in zoo and wild animals

✍ Kock, R.A. ;Jago, M. ;Gulland, F.M.D ;Lewis, J. 📂 Article 📅 1989 🏛 Elsevier ⚖ 695 KB

The effects of a peripherally selective

The effects of a peripherally selective alpha 2-adrenoceptor antagonist, MK-467, on the metabolic and cardiovascular response to exercise in healthy man.

✍ DG Sciberras; JW Reed; C Elliott; PG Blain; MR Goldberg 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 1022 KB

Comparative 5-HT2A-receptor and alpha1-a

Comparative 5-HT2A-receptor and alpha1-adrenoceptor antagonistic activity of an ergoline LEK-8829 and its degradation product LEK-1814 in rabbit isolated aorta

✍ I. Krisch; B. Bole-Vunduk; R. Rucˇman 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 139 KB

2P-0464 Carvedilol, a beta-adrenoceptor

2P-0464 Carvedilol, a beta-adrenoceptor antagonist with antioxidant activity, attenuates TNF-alpha stimulated expression of VCAM-1 and E-selectin, and adhesiveness to mononuclear cells in human aortic endothelial cells

✍ Chen, J.-W.; Lin, F.-Y.; Chen, Y.-H.; Yang, T.-L.; Chen, Y.-L.; Lin, S.-J. 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 65 KB