Beneficial effect of fibronectin administration on chronic nephritis in rats

✍ Scribed by Javier Quirós; Jesus Gonzalez-Cabrero; Jesus Egido; Gabriel Herrero-Beaumont; Juan C. Martinez-Montero

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 759 KB
• Volume: 33
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780330511

✦ Synopsis

We studied the effect of fibronectin (FN) on the course of chronic nephritis (induced by daily injections of ovalbumin) and on the clearance and catabolism of immune complexes in Wistar rats. Rats with chronic nephritis were treated with FN (2.5 mg/kg/48 hours) for 15 days after proteinuria was first detected. In rats with untreated nephritis, urinary protein levels increased from 40 & 22 mg/day (mean 2 SD) to 339 f 68 mg/day during the 15 days of the study (P < 0.0005). This statistically significant increase was not observed in rats treated with FN (mean f SD 58 f 46 mg/day to 124 f 112 mg/day). Rats treated with FN showed a higher total serum protein level than did the untreated animals (mean 2 SD 6.4 2 0.3 gm/dl versus 5.1 2 0.5 gm/dl; P < 0.0125), as well as a significant reduction in mesangial and glomerular basement membrane deposits. Untreated nephritic rats demonstrated delayed plasma clearance of 'rsI-labeled aggregated IgG (plasma halflife [Th] 3.03 f 0.6 minutes) and less catabolism of these --.