Effects of chronic administration of antidepressants on cerebral cortical adenylyl cyclase coupling in rat brain

✍ Scribed by Hiroki Kamada; Toshikazu Saito; Hiroki Ozawa; Naohioko Takahata

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 813 KB
• Volume: 23
• Category: Article
• ISSN: 0893-6609
• DOI: 10.1002/(sici)1520-6769(199807/08)23:1<55::aid-nrc6>3.0.co;2-k

✦ Synopsis

The effects on the adenylyl cyclase (AC) system of chronic administration of selective serotonin reuptake inhibitors (SSRIs) and trazodone were examined in rat brain. These drugs have a structure and site of action that differ from those of tricyclic antidepressants. Aver 21 days of treatment with tricyclic antidepressants, trazodone, and SSRIs, GppNHp-stimulated AC activity was increased in a dose-dependent manner in rat cerebral cortex membranes. In contrast to GppNHp-stimulated AC activity, no significant changes in M&l2 (20 mM)-stimulated activity were observed between the control and the antidepressant-treated groups. These results suggest that the increase in guanine nucleotide-stimulated AC activity is caused by the activation of Gs and that elevation of cellular cyclic AMP levels through the activation of Gs is a common mechanism of action of antidepressants.