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Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease

✍ Scribed by Elias Matthew Quintero; Lauren Willis; Rachel Singleton; Naida Harris; Peng Huang; Narayan Bhat; Ann-Charlotte Granholm


Book ID
113501661
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
748 KB
Volume
1093
Category
Article
ISSN
0006-8993

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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio