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Behavioral Effects of 5-HT2CReceptor Antagonism in the Substantia Nigra Zona Reticulata of the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

✍ Scribed by Susan H. Fox; Bill Moser; Jonathan M. Brotchie


Book ID
115606771
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
592 KB
Volume
151
Category
Article
ISSN
0014-4886

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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 ΞΌg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio