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Characterization of Enhanced Behavioral Responses tol-DOPA Following Repeated Administration in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

โœ Scribed by Brian Henry; Alan R. Crossman; Jonathan M. Brotchie


Book ID
115606794
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
153 KB
Volume
151
Category
Article
ISSN
0014-4886

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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 ฮผg 6โ€hydroxydopamine (6โ€OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio