BCR-ABL-negative chronic myeloid leukemia
β Scribed by Sonja Burgstaller; Andreas Reiter; Nicholas C. P. Cross
- Book ID
- 107540166
- Publisher
- Current Science Inc.
- Year
- 2007
- Tongue
- English
- Weight
- 406 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1558-8211
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We have isolated the 3Π BCR breakpoint junction of a complex BCR-ABL1 rearrangement found in leukemic cells with a cytogenetically normal karyotype, and the corresponding germline fragment that spanned the 3Π BCR recombination site. Fluorescence in situ hybridization localized the 3Π BCR recombinati
An atypical case of Philadelphia (Ph) negative, e1a2 BCR-ABL transcript positive chronic myeloid leukemia (CML) characterized with cyclic periodic leukocytosis and spontaneous remissions is reported. The patient was treated with imatinib and good hematology response with molecular remission was achi
The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visualizing one fusion signal (1F FISH) have high false p
Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications. We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript,