Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia : A case report with in vitro studies
โ Scribed by Kiyoshi Watari; Arinobu Tojo; Tokiko Nagamura-Inoue; Masaaki Matsuoka; Seiji Irie; Kenzaburo Tani; Yoshitsugu Yamada; Shigetaka Asano
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 257 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0008-543X
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Chronic neutrophilic leukemia (CNL) is a very rare myeloproliferative disorder. To determine the neoplastic origin of CNL, morphological and cytogenetical studies were made of colonies derived from hematopoietic progenitors of a patient with CNL. The patient's hematopoietic progenitors spontaneously
## BACKGROUND. T-cell lymphoid blastic phase (BP) transformation is rare in chronic myelogenous leukemia (CML). 2-amino-9-โค-D-arabinosyl-6-methoxy-9H-guanine (GW506U78), a prodrug of arabinosylguanine (ara-G), is effective in T-cell leukemias. ## METHODS. The authors present a case of a 48-year