Bcl-xL confers multi-drug resistance in several squamous cell carcinoma cell lines
β Scribed by T. Noutomi; H. Chiba; M. Itoh; H. Toyota; J. Mizuguchi
- Book ID
- 114393720
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 258 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1368-8375
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## Background: Inhibition of apoptosis, or programmed cell death, may be critical both in the development of cancer and in determining response to therapy. the authors examined the expression of two related apoptotic inhibitors, bcl-2 and bcl-xl, in pretreatment biopsies from a series of 42 patient
Nonfunctional p53 and especially upregulation of Bcl-x(L) result in advanced disease and poor prognosis of patients suffering head and neck squamous cell carcinoma (HNSCC). Aberrancies of Bcl-x(L) and/or p53 in HNSCC lead to inability of anticancer drugs to induce apoptosis. Bcl-x(L) and/or mutated