## Background: Inhibition of apoptosis, or programmed cell death, may be critical both in the development of cancer and in determining response to therapy. the authors examined the expression of two related apoptotic inhibitors, bcl-2 and bcl-xl, in pretreatment biopsies from a series of 42 patient
Bcl-Xl protein expression in laryngeal squamous cell carcinoma
β Scribed by T. Krecicki; M. Fraczek; J. Kozlak; T. Zatonski; M. Jelen; D. Dus
- Book ID
- 108705099
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 52 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1749-4478
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We investigated immunohistochemically the clinical relevance of the over-expression of the apoptosis-regulating proteins p53 and bcl-2 in a homogeneous series of 149 laryngeal squamous-cell carcinomas. p53 was over-expressed in 75 cases and bcl-2 in 39 cases. p53 and bcl-2 co-expression was found in
## Background: Bcl-2 and bax genes are known to be involved in the control of apoptotic cell death, an important mechanism of growth regulation that influences the biologic behavior of tumors. the aim of the current study was to investigate the relationship of bcl-2 and bax expression to the rate o
## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bclβ2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa