## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bcl‐2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa
Prognostic Significance of p53/bcl-2 Co-expression in Patients With Laryngeal Squamous Cell Carcinoma
✍ Scribed by Martin C. Jäckel; Ludger Sellmann; Mansur A. Dorudian; Sumaya Youssef; Làszlò Füzesi
- Book ID
- 110082397
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 311 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0023-852X
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BACKGROUND. The clinical course of laryngeal squamous cell carcinoma (LSCC) varies considerably among patients. New biologic markers are needed to facilitate the stratification of individual patients within the conventional clinicopathologic stages of LSCC. METHODS. Eighty-three LSCCs from an equal
## Background and objectives: It is generally accepted that the overexpression of p53 protein is associated with poor prognosis in breast, colorectal, and other types of cancer. however, the prognostic significance of p53 aberrations in esophageal squamous cell carcinoma has yet to be determined. w
We investigated immunohistochemically the clinical relevance of the over-expression of the apoptosis-regulating proteins p53 and bcl-2 in a homogeneous series of 149 laryngeal squamous-cell carcinomas. p53 was over-expressed in 75 cases and bcl-2 in 39 cases. p53 and bcl-2 co-expression was found in