BCl 3 - and TiCl 4 -Mediated Reductions of β-Hydroxy Ketones
✍ Scribed by Sarko, Christopher R.; Collibee, Scott E.; Knorr, Allison L.; DiMare, Marcello
- Book ID
- 120075795
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 204 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
A mild method for the selective reduction of a,b-unsaturated ketones is reported. The process described herein involves, as the active species, the low-valent titanium complex Cp 2 TiCl.
Intramolecular TiCl 4 -mediated cyclization reaction of 1,1-dimethoxy-3-hydroxy-hex-5-yne derivatives produced anti-1hydroxy-3-methoxy-cyclohex-5-ene derivatives with high diastereoselectivity via antiperiplanar manner on pseudo six-membered chair like conformation (transition state A).
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