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ChemInform Abstract: Cp2TiCl-Mediated Selective Reduction of α,β-Unsaturated Ketones.
✍ Scribed by Lionel Moisan; Christophe Hardouin; Bernard Rousseau; Eric Doris
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Under optimized conditions, a variety of ketones undergo asymmetric 1,2‐reductions almost exclusively instead of the normally observed 1,4‐reductions in the presence of in situ‐generated CuH which is ligated with an optically active bisphosphane ligand.
Copper(I) Salt Mediated 1,4-Reduction of α,β-Unsaturated Ketones Using Hydrosilanes. -The title reaction is carried out for several acyclic and cyclic α,β-unsaturated ketones in excellent yields. Sterically congested enones such as (Va) are recovered unchanged, a fact that can be applied in competit