ChemInform Abstract: CuH-Catalyzed Enantioselective 1,2-Reductions of α,β-Unsaturated Ketones.

✍ Scribed by Ralph Moser; Zarko V. Boskovic; Christopher S. Crowe; Bruce H. Lipshutz

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 70 KB
• Volume: 41
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201042027

✦ Synopsis

Abstract

Under optimized conditions, a variety of ketones undergo asymmetric 1,2‐reductions almost exclusively instead of the normally observed 1,4‐reductions in the presence of in situ‐generated CuH which is ligated with an optically active bisphosphane ligand.