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A Highly Diastereoselective TiCl4-Mediated Reduction of β-Hydroxy Ketones with BH3·py — A Very Efficient and General Synthesis of syn-1,3-Diols

✍ Scribed by Giuseppe Bartoli; Marcella Bosco; Enrico Marcantoni; Massimo Massaccesi; Samuele Rinaldi; Letizia Sambri


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
332 KB
Volume
2001
Category
Article
ISSN
1434-193X

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Highly Stereoselective and Efficient Add
✍ Giuseppe Bartoli; Marcella Bosco; Emanuela Di Martino; Enrico Marcantoni; Letizi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB

A highly efficient and stereoselective technique for additions to syn-β-alkyl-β-hydroxy-α-methyl ketones is now available. The methodology is based on the conversion of the starting material into a trichlorotitanium alkoxide derivative, which is able to assume a stable cyclic arrangement exhibiting