Cp2TiCl-mediated selective reduction of α,β-unsaturated ketones
✍ Scribed by Lionel Moisan; Christophe Hardouin; Bernard Rousseau; Eric Doris
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 56 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A mild method for the selective reduction of a,b-unsaturated ketones is reported. The process described herein involves, as the active species, the low-valent titanium complex Cp 2 TiCl.
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## Abstract Eleven structurally different α, β‐unsaturated ketones were subjected to the __Clemmensen__ reduction under anhydrous conditions using amalgamated zinc, hydrogen chloride in a solution of ethyl ether, and acetic anhydride. In all cases but one the formation of cyclopropyl acetates was o