Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells
✍ Scribed by Laura Sanz; José A Garcia-Marco; Benito Casanova; Marı́a Teresa de la Fuente; Mercedes Garcı́a-Gila; Ángeles Garcia-Pardo; Augusto Silva
- Book ID
- 116287971
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 460 KB
- Volume
- 315
- Category
- Article
- ISSN
- 0006-291X
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B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 ؉ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a
## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci