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Hydroxychloroquine (Hcq) Induces apoptosis in b-chronic lymphocytic leukemia cells (B-cll) Via activation of CASPASE-3 and down-regulation of BCL-2

✍ Scribed by L. Lagneaux; A. Delforge; S. Carlier; M. Bernier; D. Bron


Book ID
114216540
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
20 KB
Volume
28
Category
Article
ISSN
0301-472X

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## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci