Relationship between nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) and protein expression of Bcl-2, Bax, Bcl-X and p53

Significance of phosphotyrosine proteins

Significance of phosphotyrosine proteins, Bcl-2 and p53 for apoptosis in resting b-chronic lymphocytic leukemia (CLL) cells

✍ Nongnit Laytragoon-Lewin; Eva D. Rossmann; Juan Castro; Håkan Mellstedt 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 139 KB

## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci