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Interferon-α-Mediated Prevention of in Vitro Apoptosis of Chronic Lymphocytic Leukemia B Cells: Role of bcl-2 and c-myc

✍ Scribed by Nadia Chaouchi; Christine Wallon; Joelle Taieb; Marie Thérèse Auffredou; Gerard Tertian; François M. Lemoine; Jean François Delfraissy; Aimé Vazquez


Book ID
112240564
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
617 KB
Volume
73
Category
Article
ISSN
1090-2341

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## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci