The present study was designed to clarify whether bcl-xL is involved in the development of carcinoma in the stomach. Levels of bcl-xL and bcl-2 mRNA were determined by a reverse-transcription/polymerase-chain reaction in endoscopic gastric biopsy specimens from 10 control subjects, 11 patients with
Bcl-2 expression and allelic loss of thep53gene in gastric carcinomas
β Scribed by M. Saegusa; Y. Takano; Y. Kamata; I. Okayasu
- Book ID
- 112498227
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 821 KB
- Volume
- 122
- Category
- Article
- ISSN
- 1432-1335
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Background and Procedure. The p53 gene homologue, p73, is located on the 1p36-3 locus, which is frequently deleted in human neuroblastoma (NB). A survey of 61 NB showed that among 33% of informative cases, p73 loss of heterozygosity (LOH) occurred in 7 of 20 (35%). Results. LOH pattern of vicinal ma