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Genomic and allelic expression status of thep73 gene in human neuroblastoma

✍ Scribed by Barrois, M. ;Eychenne, M.K. ;Terrier-Lacombe, M.J. ;Duarte, N. ;Dubourg, C. ;Douc-Rasy, S. ;Chompret, A. ;Khagad, M. ;Hartmann, O. ;Caput, D. ;B�nard, J.

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
150 KB
Volume
36
Category
Article
ISSN
0098-1532

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✦ Synopsis

Background and Procedure. The p53 gene homologue, p73, is located on the 1p36-3 locus, which is frequently deleted in human neuroblastoma (NB). A survey of 61 NB showed that among 33% of informative cases, p73 loss of heterozygosity (LOH) occurred in 7 of 20 (35%). Results. LOH pattern of vicinal markers suggested that the p73 gene could not be considered as the candidate NB suppressor gene. Moreover, comparative measurements of allelic expression in tumors and corresponding pa-tient lymphocytes indicate that pure biallelism is much more frequent in lymphocytes than in tumors (71% vs 30%, P = 0.05), which suggests that disequilibrated allelic expression is associated with NB disease. Conclusion. Therefore, in the p73 LOH NBs, the p73 gene could be altered in the maintained allele not by mutations [Ishimiya et al.:

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