The products of bcl-2 and p53 genes are involved in the regulation of apoptosis and proliferation and have been associated with prognosis in several malignancies, including colorectal adenocarcinoma. Although 2 European studies have reported a prognostic significance of Bcl-2 expression in colorecta
Prognostic significance of Bcl-2 and p53 expression in gastric cancer
β Scribed by HyeonKook Lee; HyeSeung Lee; Han-Kwang Yang; WooHo Kim; KuhnUk Lee; KukJin Choe; Jin-Pok Kim
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 340 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0179-1958
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The presence of the nuclear phosphoprotein p53 was investigated in a series of 120 consecutive gastric carcinomas. This immunohistochemical study on formalin-fixed, paraffin-embedded material found p53 expression in 43 per cent ( ~5 1 ) of carcinomas using a monoclonal antibody (DO-l), whereas no im
## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bclβ2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa