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Over-expression of bcl-xL gene in human gastric adenomas and carcinomas

✍ Scribed by Shinya Kondo; Yasuhisa Shinomura; Shuji Kanayama; Yoshifumi Higashimoto; Jun-Ichiro Miyagawa; Takeshi Minami; Tatsuya Kiyohara; Shinichiro Zushi; Shinji Kitamura; Koji Isozaki; Yuji Matsuzawa

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
543 KB
Volume
68
Category
Article
ISSN
0020-7136

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✦ Synopsis

The present study was designed to clarify whether bcl-xL is involved in the development of carcinoma in the stomach. Levels of bcl-xL and bcl-2 mRNA were determined by a reverse-transcription/polymerase-chain reaction in endoscopic gastric biopsy specimens from 10 control subjects, 11 patients with adenomas and 14 patients with carcinomas. In 6 of 11 adenomas, 5 of 8 early carcinomas and 3 of 6 advanced carcinomas, the bcl-xL gene was over-expressed. In carcinomas, over-expression of the bcl-xL gene was observed in 6 of 9 intestinal-type carcinomas and 2 of 5 diffuse-type carcinomas. No correlation was observed between bcl-xL and bcl-2 gene expression. In cases in which the bcl-xL gene was over-expressed, an apparent increase in the protein level of Bcl-xL was observed by immunoblot analysis and intense Bcl-x immunoreactivity was detected immunohistochemically within the tumor cells. In conclusion, we showed that bcl-xL is over-expressed in gastric carcinomas at both the RNA and protein levels, suggesting that over-expression of bcl-xL may play a role in gastric carcinogenesis.

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