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Base specificity in the binding of benzo[a]pyrene diol epoxide to simian virus 40 DNA

✍ Scribed by Mengle, Laurel; Gamper, Howard; Bartholomew, James


Book ID
122437996
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
320 KB
Volume
5
Category
Article
ISSN
0304-3835

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The importance of intercalation in the c
✍ Michael C. MacLeod πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 English βš– 513 KB

The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac