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Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide

✍ Scribed by Huifang Zhu; Yanfeng Fan; Jing Shen; Hongyan Qi; Jimin Shao


Book ID
116455062
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
744 KB
Volume
33
Category
Article
ISSN
1382-6689

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The importance of intercalation in the c
✍ Michael C. MacLeod 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 513 KB

The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac