The fluorescence of the pyrenyl chromophore in a covalently linked benzo[a]pyrene diol epoxide-N\*-2'deoxyguanosine complex, and in noncovalent 7,8,9,lD\_tetrahydroxytetrahydm~nzo[a]pyrrnedeoxyguanosine complexes, is strongly quenched in aqueous solution by a photoinduced electron transfer mechanism
Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA
✍ Scribed by MEEHAN, T.; STRAUB, K.; CALVIN, M.
- Book ID
- 109707446
- Publisher
- Nature Publishing Group
- Year
- 1977
- Tongue
- English
- Weight
- 319 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/269725a0
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📜 SIMILAR VOLUMES
The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac
## Abstract The hydrocarbon‐deoxyribonucleoside adducts formed in mouse skin DNA have been determined following topical application of an initiating dose of benzo(a)pyrene to Swiss mice, a strain shown to be susceptible to benzo(a)pyrene‐induced skin carcinogenesis. Several DNA‐bound products were