Recently we prepared the enetrione, I, and demonstrated that intermolecular additions of nucleophiles to the double bond triggers a series of intramolecular condensations leading to products of relevance to steroids. 1 We now report an interesting isomerization of I, occasioned by its treatment wit
Base-catalyzed cyclization of an oxoalkylpyrimidine
β Scribed by William E. Barnett; Ralph F. Koebel
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 181 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Developments concerning the fundamental role of nucleic acids in molecular t 'ology hove caused a dramatic increase of fundamental research into the chemistry of simple purine and pyrimidine'12 compounds.
Even so, there ore many areas where our chemical knowledge is scant. This paper deals with one such orea, reactions of pyrimidine ketones.
π SIMILAR VOLUMES
Acylation of 1,3-disubstituted thioureas with methyl malonyl chloride followed by base-catalyzed cyclization leads to the preparation of 1,3-disubstituted-2-thiobarbituric acids in high yield.
The reaction of 2-alkyl-2-p-toluenesulfonoxymethylcyclohexanones with base has been found by three groups to give bicyclo[3.
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