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Preparation of Carbocycles via Base-Catalyzed Endo-Mode Cyclization of Allenes.

โœ Scribed by Chisato Mukai; Norikazu Kuroda; Rie Ukon; Rumiko Itoh


Publisher
John Wiley and Sons
Year
2005
Weight
44 KB
Volume
36
Category
Article
ISSN
0931-7597

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Stereoselective Total Synthesis of (ยฑ)-Swainsonine Based on endo Mode Cyclization. -The crucial step in the synthesis of title alkaloid (IX) is the endo mode cyclization of cis epoxide (II) by successive treatment with Co 2 (CO) 8 , Lewis acid, and CAN. The trans-piperidine (III) is formed as major