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An efficient acylation/base-catalyzed cyclization of thioureas affords N,N′-disubstituted thiobarbituric acids

✍ Scribed by Perry C Heath; Charles Q Huang; Richard F Lowe; James R McCarthy; Leland O Weigel; Jeffery P Whitten

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 69 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00011-9

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✦ Synopsis

Acylation of 1,3-disubstituted thioureas with methyl malonyl chloride followed by base-catalyzed cyclization leads to the preparation of 1,3-disubstituted-2-thiobarbituric acids in high yield.

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ChemInform Abstract: An Efficient Acylat

ChemInform Abstract: An Efficient Acylation/Base-Catalyzed Cyclization of Thioureas Affords N,N′-Disubstituted Thiobarbituric Acids.

✍ Perry C. Heath; Charles Q. Huang; Richard F. Lowe; James R. McCarthy; Leland O. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

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