𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Avoidance of “First-Pass” Elimination of Rectally Administered Propranolol in Relation to the Site of Absorption in Rats

✍ Scribed by Leo G. J. de Leede; Albertus G. de Boer; Jacques P. J. M. Havermans; Douwe D. Breimer

Book ID
114421354
Publisher
Springer US
Year
1984
Tongue
English
Weight
918 KB
Volume
01
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Rectal absorption of nitroglycerin in th
Rectal absorption of nitroglycerin in the rat: Avoidance of first-pass metabolism as a function of rectal length exposure
✍ A. Kamiya; H. Ogata; Ho-Leung Fung 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 511 KB

Nitroglycerin administered orally undergoes substantial presystemic elimination. It was shown recently that first-pass hepatic metabolism of high clearance drugs can be substantially avoided uia rectal administration. In applying this concept to nitroglycerin in rats, it was found that unrestricted

Avoidance of hepatic first-pass effect i
Avoidance of hepatic first-pass effect in the rabbit via rectal route of administration
✍ Nahoko Kurosawa; Eiji Owada; Keiji Ito 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 2 views

To assess avoidance of hepatic first-pass effect of drugs, we undertook in situ experiments using rectal administration of lidocaine in the rabbit. We also employed in situ duodenal route to estimate first-pass metabolism across the gastrointestinal mucosa. Rabbits were administered lidocaine HCl in