Nitroglycerin administered orally undergoes substantial presystemic elimination. It was shown recently that first-pass hepatic metabolism of high clearance drugs can be substantially avoided uia rectal administration. In applying this concept to nitroglycerin in rats, it was found that unrestricted
Avoidance of First-Pass Metabolism of Propranolol after Rectal Administration as a Function of the Absorption Site
β Scribed by Kikuo Iwamoto; Jun Watanabe
- Book ID
- 114421252
- Publisher
- Springer US
- Year
- 1985
- Tongue
- English
- Weight
- 380 KB
- Volume
- 02
- Category
- Article
- ISSN
- 0724-8741
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