Automated synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module
✍ Scribed by Zibo Li; Hancheng Cai; Peter S. Conti
- Book ID
- 116799668
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 397 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0969-8051
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📜 SIMILAR VOLUMES
## Abstract Synthesis of 2′‐deoxy‐2′‐[^18^F]fluoro‐5‐methyl‐1‐__β__‐D‐arabinofuranosyluracil ([^18^F]‐FMAU) is reported. 2‐Deoxy‐2‐[^18^F]fluoro‐1,3,5‐tri‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** was prepared by the reaction of the respective triflate **1** with tetrabutylammonium[^18^F]fluoride. Th
## Abstract Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐__β__‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** with protected uracil derivatives **3a–e** followed by hydrolysis and high‐performance liquid