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Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography

✍ Scribed by Alf T. Andresen; Knut E. Rasmussen; Hans E. Rugstad


Book ID
107997078
Publisher
Elsevier Science
Year
1993
Weight
579 KB
Volume
621
Category
Article
ISSN
0378-4347

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## Abstract Melagatran is an active thrombin inhibitor showing oral and parenteral bioavailability for antithrombotic therapy. A simple and convenient liquid chromatographic method has been developed and applied to the analysis of melagatran in rabbit plasma. The clean‐up and separation of the samp