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Determination of melagatran in rabbit plasma by high-performance liquid chromatography with automated column switching

✍ Scribed by Byoung-Hyoun Kim; Sun Young Park; Nak Hee Choi; Jong Hoa Ok

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
138 KB
Volume
17
Category
Article
ISSN
0269-3879

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✦ Synopsis

Abstract

Melagatran is an active thrombin inhibitor showing oral and parenteral bioavailability for antithrombotic therapy. A simple and convenient liquid chromatographic method has been developed and applied to the analysis of melagatran in rabbit plasma. The clean‐up and separation of the sample solutions were performed by automated on‐line column switching HPLC. The method validation shows the suitability of the column switching liquid chromatographic system for the quantitation of melagatran in biological fluids. Copyright © 2003 John Wiley & Sons, Ltd.

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