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Aurones serve as probes of β-amyloid plaques in Alzheimer’s disease

✍ Scribed by Masahiro Ono; Yoshifumi Maya; Mamoru Haratake; Kazuhiro Ito; Hiroshi Mori; Morio Nakayama


Book ID
116295289
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
319 KB
Volume
361
Category
Article
ISSN
0006-291X

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t