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Novel Radioiodinated Aurones as Probes for SPECT Imaging of β-Amyloid Plaques in the Brain

✍ Scribed by Maya, Yoshifumi; Ono, Masahiro; Watanabe, Hiroyuki; Haratake, Mamoru; Saji, Hideo; Nakayama, Morio


Book ID
121445789
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
703 KB
Volume
20
Category
Article
ISSN
1043-1802

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t