“Atypical” multidrug resistance in human ovarian cancer cell line A2780 selected for resistance to doxorubicin (A2780 DX3)
✍ Scribed by Guido Cimoli; Monica Valenti; Elvira Noviello; Silvio Parodi; Alessandra Mazzoni; Elisabetta Rovini; Fabio De Sessa; Patrizia Russo
- Book ID
- 112496837
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 994 KB
- Volume
- 121
- Category
- Article
- ISSN
- 1432-1335
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A possible novel mechanism of cross-resistance to cisplatin (CDDP) in the doxorubicin-resistant ovarian-cancer cell line A2780-DX3, which displays atypical multidrug resistance, is presented. A2780-DX3 is found to be more resistant than the parental line A2780 in terms of CDDP-induced cytotoxicity a
## Abstract A doxorubicin‐resistant variant of the human small‐cell lung‐cancer cell line N592 was selected by __in vitro__ continuous exposure to increasing drug concentrations. The aim of this study was to examine the cross‐resistance pattern, cellular pharmacokinetics of doxorubicin and expressi