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Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

✍ Scribed by Mariëlle C. Haks; Juliette M. Lefebvre; Jens Peter H. Lauritsen; Michael Carleton; Michele Rhodes; Toru Miyazaki; Dietmar J. Kappes; David L. Wiest


Book ID
116570443
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
869 KB
Volume
22
Category
Article
ISSN
1074-7613

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✍ Georges Leclercq; Magda De Smedt; Jean Plum 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 517 KB

Several groups have described that a low percentage of in vitro cultured Tcell receptor (TcR) yl6 cells express CD8. Contrary toTcR alp cells, however, CD8 on these TcR y/6 cells was shown to be a CD8a homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vitro culture