First total synthesis of (+)-crassalacto
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V. Shekhar; D. Kumar Reddy; V. Suresh; D. Chanti Babu; Y. Venkateswarlu
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Article
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2010
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Elsevier Science
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French
β 245 KB
A simple and highly efficient first total synthesis of cytotoxic (+)-crassalactone A starting from (R)-mandelic acid is described. The strategy involves the osmium tetroxide-catalyzed cis-hydroxylation and the stereoselective addition of ethyl lithiopropiolate to a chiral aldehyde intermediate as ke