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Asymmetric Total Synthesis of (+)-Milbemycin D

โœ Scribed by Crimmins, Michael T.; Al-awar, Rima S.; Vallin, Isabelle M.; Hollis, W. Gary; O'Mahony, Rosemary; Lever, John G.; Bankaitis-Davis, Danute M.


Book ID
111980130
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
931 KB
Volume
118
Category
Article
ISSN
0002-7863

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A highly stereocontrolled synthesis of the Cl 1 to C3 1 fragment of the potent antimicrobial agent milbemycin D has been completed. This approach utilizes a unique hydrolysis-cyclization to construct the spiroketal portion of the molecule. The milbemycins 2 and the avermectins3 are two structurall