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Total synthesis of milbemycin .beta.3

โœ Scribed by Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.


Book ID
118043059
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
485 KB
Volume
104
Category
Article
ISSN
0002-7863

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A highly stereocontrolled synthesis of the Cl 1 to C3 1 fragment of the potent antimicrobial agent milbemycin D has been completed. This approach utilizes a unique hydrolysis-cyclization to construct the spiroketal portion of the molecule. The milbemycins 2 and the avermectins3 are two structurall