A simple and highly efficient first total synthesis of cytotoxic (+)-crassalactone A starting from (R)-mandelic acid is described. The strategy involves the osmium tetroxide-catalyzed cis-hydroxylation and the stereoselective addition of ethyl lithiopropiolate to a chiral aldehyde intermediate as ke
✦ LIBER ✦
A Chiron Approach for the Total Synthesis of Crassalactone A
✍ Scribed by Singh Yadav, Jhillu; Maheswara Rao, Gokada; Thirupathaiah, Bodakuntala
- Book ID
- 121767905
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- German
- Weight
- 176 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0018-019X
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