Asymmetric synthesis of the milbemycin .beta.3 spiroketal subunit
โ Scribed by Holoboski, Mark A.; Koft, Emil
- Book ID
- 120354675
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 678 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
## w : The crystalline spiroketal sub-unit 2 has been synthesized in ten steps from the 2S,3Rdiol2 using a remote partial stereocontrol for the aldolisation step. The unique biological activity of milbemycins and avermectins as well as their challenging structural features (1) led us to develop a
Using a Ru catalyzed cyclixation-addition, a short synthesis of the spiroketal core corresponding to the natural enantiomer of (-)-calyculin A from R-pantolactone emerges. Calyculin A (1). isolated from the marine sponge Discodennia calyx, is a nanomolar inhibitor of two of the