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A synthesis of the spiroketal subunit of (−)-calyculin A

✍ Scribed by Barry M. Trost; John A. Flygare

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 302 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73111-x

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✦ Synopsis

Using a Ru catalyzed cyclixation-addition, a short synthesis of the spiroketal core corresponding to the natural enantiomer of (-)-calyculin A from R-pantolactone emerges.

Calyculin A (1). isolated from the marine sponge Discodennia calyx, is a nanomolar inhibitor of two of the

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