𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Total Synthesis of (+)-Calyculin A and (−)-Calyculin B: Asymmetric Synthesis of the C(9−25) Spiroketal Dipropionate Subunit

✍ Scribed by Smith, Amos B.; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Salvatore, Brian A.; Spoors, P. Grant; Duan, James J.-W.


Book ID
120039256
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
872 KB
Volume
121
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


A synthesis of the spiroketal subunit of
✍ Barry M. Trost; John A. Flygare 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 302 KB

Using a Ru catalyzed cyclixation-addition, a short synthesis of the spiroketal core corresponding to the natural enantiomer of (-)-calyculin A from R-pantolactone emerges. Calyculin A (1). isolated from the marine sponge Discodennia calyx, is a nanomolar inhibitor of two of the